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Allergies: Persons with allergies in order to pollen, bee stings, or honey ought to exercise extreme extreme care, as severe allergic reactions (anaphylaxis) can occur. Symptoms range from hives, wheezing, inflammation, and dizziness. Medication Interactions: If you're on blood thinners (like warfarin) or other medications, seek advice from your doctor before taking Royal Gel, as it may interact.